mental tau memory levodopa dementia disease anxiety gene ragged antiepileptic serotonin antidepressant alzheimers pin annulus osteosarcoma personality trauma hippocampal ad cohesion pain panic cognitive addiction schwann scale cognition insomnia parkinsons ideation clock nerve spinal mutant alzheimer elegans neuroimaging neuron mood emotion emotional amyloid neuroscience axon stroke psychiatry psychologic psychological neurotoxicity depressive neurotrophic circadian autism depression suicidal suicide blues mind juvenile migraine sleep microglial synapse brain synaptic