Ä¡¸Å¿Í ³ú ¾Æ¹Ð·ÎÀÌµå º´¸®¿¡ µû¸¥ À¯º´·ü °ü·Ã¼º : ¸ÞŸºÐ¼®
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
¾ËÃ÷ÇÏÀ̸Ӻ´ (Alzheimer disease, AD)Àº Ä¡¸ÅÀÇ °¡Àå ÈçÇÑ ¿øÀÎÀ̸ç 2010 ³â¿¡ ¾à 25,000,000¸íÀÌ ¹ßº´ÇÏ¿´À¸¸ç, ±â´ë Æò±Õ¼ö¸íÀÇ ¿¬ÀåÀ¸·Î 2030³â¿¡´Â µÎ ¹è°¡ µÉ °ÍÀ¸·Î ¿¹»óµÈ´Ù. Ä¡¸Å¹ßº´¿¡ ´ëÇÑ ¿¹¹æ°ú ±âÀüÀ» ÀÌÇØÇϱâ À§ÇÏ¿© ´Ù¾çÇÑ ¹ÙÀÌ¿À¸¶Ä¿¸¦ ÀÌ¿ëÇÑ À¯ÀüÇÐÀûÀÎ ¿¬±¸°¡¿îµ¥, ´ë³ú ¾Æ¹Ð·ÎÀ̵å -β ÀÀÁý¿¡ ´ëÇÑ ¾ËÃ÷ÇÏÀÌ¸Ó (Alzheimer disease, AD)ÀÇ º´¸®ÇÐÀû ¿¬±¸´Â ¿À·¡ Àü ºÎÅÍ ¼öÇàµÇ¾ú´Ù. ´ë³ú ¾Æ¹Ð·ÎÀ̵å -β ÀÀÁýÀº ¾ËÃ÷ÇÏÀÌ¸Ó (Alzheimer disease, AD)ÀÇ Ãʱ⠺´¸®ÇÐÁõ»óÀ¸·Î, Ä¡¸Å°¡ ¹ßº´Çϱ⠼ö½Ê ³â ÀüºÎÅÍ ½ÃÀ۵ȴÙ. ADÀÇ ¹ß´ÞÀ» ÀÌÇØÇÏ°í ¿¹¹æÀ» À§ÇÏ¿© º» ¿¬±¸´Â Ä¡¸Å°¡¾ø´Â »ç¶÷ÀÇ ¾Æ¹Ð·ÎÀÌµå º´¸®ÀÇ À¯º´·ü°ú °ü·Ã¼º¿¡ ´ëÇÏ¿© ÅëÇÕ ¿¬±¸ÀÌ´Ù.
º» ¿¬±¸¿¡¼´Â °³º° Âü°¡ÀÚµéÀÇ µ¥ÀÌÅ͸¦ ¸ÞŸºÐ¼® (Meta-analysis)À» »ç¿ëÇÏ¿© ºÐ¼®ÇÏ¿´À¸¸ç, Á¤»ó ÀÎÁö»óÅÂ(Normal Cognition), ÁÖ°üÀû ÀÎÁöÀå¾Ö (Subjective Cognitive Impairment, SCI) ¶Ç´Â °æÁõ ÀÎÁöÀå¾Ö (Mild Cognitive Impairment, MCI)¸¦ °¡Áø Âü°¡ÀÚµéÀ» ±¸ºÐÇÏ¿© ³úÀÇ ¾Æ¹Ð·ÎÀÌµå º´¸®¸¦ ¹ÙÀÌ¿À¸¶Ä¿·Î »ç¿ëÇÏ¿© Ä¡¸Å À¯º´·üÀ» ºÐ¼®ÇÑ ¿¬±¸ÀÌ´Ù.
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
ÀÓ»óÁú¹®
|
Ä¡¸Å¹ÙÀÌ¿À¸¶ÅÍ ¿¬±¸¿¡¼ ³úÀÇ ¾Æ¹Ð·ÎÀÌµå º´¸®(cerebral amyloid pathology) »óÅ°¡ Ä¡¸Å¹ßº´°ú °ü·Ã¼ºÀÌ ÀÖ½À´Ï±î?
|
±Ù°Å±â¹Ý´äº¯
|
¾Æ¹Ð·ÎÀÌµå ¾ç¼º(Amyloid positivity)Àº ±³À°¼öÁØÀÌ º¸´Ù ³ôÀ»¼ö·Ï ´õ¿í ÈçÇÏ°Ô ³ªÅ¸³ªÁö¸¸, ¼ºº°À̳ª ¹ÙÀÌ¿À¸¶Ä¿ ¾ç»ó°ú´Â °ü·Ã¼ºÀÌ ¾øÀ½À» ³ªÅ¸³»¾ú´Ù. ÀÌ ¿¬±¸°á°ú¸¦ ÅëÇÏ¿© ¾Æ¹Ð·ÎÀÌµå ¾ç¼ºÀÇ Ã¹ ¹ß´Þ°ú Ä¡¸Å ¹ßº´ »çÀÌ¿¡´Â 20-30 ³â°£ÀÇ °£°ÝÀÌ ÀÖÀ½À» ³ªÅ¸³»¾ú´Ù.
|
¼ÁöÁ¤º¸
|
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis (2015). JAMA . May 19; 313(19): 1924–1938. doi: 10.1001/jama.2015.4668
|
Áúº´Æ¯¼º
|
Alzheimer disease (AD)
|
¿¬±¸¼³°è
|
Meta-analysis
|
¿¬±¸´ë»ó
|
Àüü 7,538¸í Âü°¡ÀÚ
- Á¤»ó ÀÎÁö(Normal Cognition) : 2,914¸í(38%)
- ÁÖ°üÀû ÀÎÁöÀå¾Ö (SCI) : 697¸í(9%)
- °æÁõ ÀÎÁöÀå¾Ö(MCI) : 3,972¸í(52%)
|
Ä¡·áÁßÀç
|
¹ÙÀÌ¿À¸¶Ä¿ (Biomarker): Cerebral amyloid-beta aggregation
|
Æò°¡ÁöÇ¥
|
- APOE-ε4 carrier status
- Age
- Cognitive Status
|
¿¬±¸°á°ú
|
1. ¾Æ¹Ð·ÎÀÌµå ¾ç¼ºÀº Á¤»óÀÎÁö¸¦ °¡Áø Âü°¡ÀÚ¿Í ºñ±³ÇÏ¿© MCI ȯÀÚ¿¡¼ ¾à 2 ¹è Á¤µµ ÈçÇÏ°Ô ³ªÅ¸³µ´Ù. (mean difference, 25% [95% CI, 22% to 28%]; P < .001) or SCI (mean difference, 23% [95% CI, 14% to 32%]; P < .001), while it did not differ between participants with normal cognition and SCI (mean difference, 2% [95% CI, −6% to 10%]; P = .62).
2. ¾Æ¹Ð·ÎÀÌµå ¾ç¼ºÀº ¸ðµç Áø´Ü±×·ì¿¡¼ ¿¬·É¿¡ µû¶ó Áõ°¡ÇÏ¿´´Ù.
3. APOE-ε4 Äɸ®¾î (APOE-ε4 carriers)±ºÀº °¢ Áø´Ü±×·ì¿¡¼ ºñ Äɸ®¾î ±ºº¸´Ù Àý´ë À¯º´·üÀÌ 10 ~ 40 % ´õ¿í ³ô°Ô ³ªÅ¸³µ´Ù.
4. Á¤»óÀÎÁö ±â´ÉÀ» °¡Áø Âü°¡ÀÚÀÇ ¿¬·É°ü·Ã ¾Æ¹Ð·ÎÀÌµå ¾ç¼º Áõ°¡´Â ³ªÀÌ º° AD À¯Çü Ä¡¸Å À¯º´·ü ÃßÁ¤°ú º´ÇàÇÏ¿© ¾à 20 ³âÀÇ °³ÀԱⰣÀ» º¸¿´´Ù.
5. º» ¿¬±¸¸¦ ÅëÇÏ¿© ADÇü Ä¡¸ÅÀÇ ÁÖ¿ä À§ÇèÀÎÀÚÀÎ ¾Æ¹Ð·ÎÀÌµå ¾ç¼ºÀÌ Ãʱâ AD¸¦ ¹Ý¿µÇÑ´Ù´Â °¡¼³¿¡ ´ëÇÑ ´õ ¸¹Àº Áõ°Å¸¦ Á¦°øÇÏ¿´´Ù.
|
±Ù°Å¼öÁØ
|
High
|
ÀÛ¼ºÀÚ
|
ÀÇ°úÇבּ¸Á¤º¸¼¾ÅÍ(MedRIC)
Copyright © 2015 Medical Research Information Center (MedRIC) Editors
|